The Science of Longevity: Understanding NAD+ Therapy

At SkinArtMD in Burnaby, we believe that aesthetic excellence is inextricably linked to cellular health. As we navigate 2026, the frontier of anti-aging has shifted from surface-level treatments to the very foundations of human biology. One of the most significant advancements in this realm is the clinical application of Nicotinamide Adenine Dinucleotide (NAD+).

Learn more about NAD+ Therapy and how it integrates into a comprehensive longevity strategy. While many patients seek us out for visible rejuvenation, the science of NAD+ Therapy offers a deeper opportunity to revitalize the body from the inside out.

The Biochemistry of NAD+: The Master Coenzyme

Nicotinamide adenine dinucleotide is a critical coenzyme found in every living cell. It exists in two forms: NAD+ (the oxidized form) and NADH (the reduced form). Together, they form a redox couple essential for energy metabolism.

Mechanism of Action: Mitochondrial Respiration

The primary role of NAD+ is in the mitochondria—the powerhouses of the cell. Through the electron transport chain, NAD+ facilitates the conversion of nutrients into adenosine triphosphate (ATP), the primary energy currency of the body. Without sufficient NAD+ levels, mitochondrial efficiency declines, leading to what researchers often describe as "cellular fatigue."

Sirtuins and the Longevity Pathway

Beyond energy production, NAD+ serves as a vital substrate for sirtuins, a family of proteins (SIRT1-SIRT7) often referred to as the "guardians of the genome." Sirtuins are responsible for regulating cellular health, aging processes, and DNA repair. However, sirtuins are NAD+-dependent; they cannot function without a steady supply of this molecule. As we age, our natural NAD+ levels decline, which in turn diminishes sirtuin activity, leading to accelerated cellular aging.

DNA Repair and PARPs

NAD+ is also consumed by Poly(ADP-ribose) polymerases (PARPs), enzymes that respond to DNA damage. In an environment of chronic oxidative stress, PARP activity increases, further depleting the available pool of NAD+. This competition for NAD+ between energy production, sirtuin activation, and DNA repair is a central focus of modern longevity medicine. Book a Consultation with our team in Burnaby to discuss how these pathways impact your specific health goals.

Clinical Evidence: What the Research Says

The transition of NAD+ from a laboratory curiosity to a clinical longevity treatment is supported by a growing body of peer-reviewed literature.

1. Metabolic Health and Insulin Sensitivity: In a landmark study by Yoshino et al., published in Science, researchers demonstrated that NAD+ supplementation could significantly improve muscle insulin sensitivity and metabolic signaling. This suggests that maintaining high NAD+ levels may help mitigate age-related metabolic decline.

2. Vascular Rejuvenation: Research by Das et al., published in Cell, indicated that increasing NAD+ levels could stimulate the growth of new blood vessels and improve blood flow, effectively "reversing" the vascular aging of muscle tissue in animal models. This has profound implications for physical stamina and tissue oxygenation.

3. Cognitive Support: Imai and Guarente, writing in NPJ Aging and Mechanisms of Disease, have highlighted the role of the NAD+/Sirtuin axis in neuroprotection. Their work suggests that maintaining NAD+ levels is crucial for protecting neurons against oxidative stress and inflammatory damage, which are hallmarks of cognitive decline.

4. Human Safety and Bioavailability: A study by Clement et al., in Nature Communications, confirmed that intravenous administration of NAD+ is a safe and effective way to rapidly increase systemic levels of the coenzyme, bypassing the limitations of oral absorption.

At SkinArtMD, we monitor these developments closely to ensure our Burnaby patients receive evidence-based care. Book a Consultation to review how this clinical evidence applies to your longevity journey.

Comparing NAD+ Delivery Methods

While lifestyle changes can influence NAD+ levels, clinical intervention is often required to achieve therapeutic concentrations. Below is a comparison of common approaches:

Candidate Evaluation: Is NAD+ Therapy Right for You?

Because NAD+ is a fundamental biological molecule, many adults in the Greater Vancouver area can benefit from supplementation. However, at SkinArtMD, every treatment plan begins with a rigorous medical evaluation. Dr. Sharon Fong, a CPSBC-registered physician, oversees our clinical protocols to ensure patient safety and efficacy.

Who Should Consider NAD+ Therapy?

• Individuals experiencing "Brain Fog": If you struggle with mental clarity or focus, NAD+ may help optimize neuronal energy.
• Patients with Chronic Fatigue: Those feeling depleted despite adequate rest often find mitochondrial support transformative.
• The Longevity-Minded Professional: Individuals in high-stress environments in Burnaby who want to maintain peak cognitive and physical performance.
• Athletes: Those looking to improve recovery times and cellular oxygenation.

Physician Oversight and Safety

Under the guidance of Dr. Sharon Fong, we evaluate your medical history, current medications, and specific aging concerns. While NAD+ is generally well-tolerated, physician oversight is critical to determine the correct dosage and frequency. Our bilingual team (English and Mandarin) ensures that every patient fully understands the process and expected outcomes.

What to Expect During Your Treatment

At our Metrotown area clinic in Burnaby, we prioritize your comfort and safety.

1. Consultation: A deep dive into your health history and goals.
2. The Session: Depending on whether you choose IV or injection therapy, the session can last from 15 minutes to several hours (for slow-drip IVs).
3. The Sensation: Some patients feel a mild "flush" or chest pressure during IV administration; this is normal and managed by adjusting the drip rate.
4. Post-Treatment: Most patients report a sense of heightened mental clarity and physical energy within 24 to 48 hours.

Why Choose SkinArtMD in Burnaby?

Choosing a clinic for longevity treatments requires trust in medical expertise. SkinArtMD stands out in the Greater Vancouver area for several reasons:

• Physician-Led Care: All protocols are designed and supervised by Dr. Sharon Fong, ensuring the highest standards of the College of Physicians and Surgeons of British Columbia (CPSBC).
• Bilingual Excellence: We offer full consultations and support in both English and Chinese (Mandarin), ensuring clear communication for our diverse community.
• Personalized Protocols: We don't believe in one-size-fits-all. Your NAD+ dosage is tailored to your weight, age, and health objectives.
• Advanced Technology: Our Burnaby facility is equipped with the latest medical technology to ensure a sterile, comfortable, and efficient experience.

Many of our clients in Burnaby have found that NAD+ Therapy is the "missing link" in their wellness routine, providing the energy they need to fully engage with their aesthetic treatments and lifestyle goals.

Frequently Asked Questions

How many sessions of NAD+ Therapy do I need?

Individual needs vary. Some patients benefit from an initial loading phase of 3-5 sessions, followed by monthly maintenance. Book a Consultation for a personalized recommendation.

Is NAD+ Therapy approved by Health Canada?

NAD+ is used in clinical settings across Canada. At SkinArtMD, we use high-quality formulations and adhere to all safety guidelines set forth by Health Canada and the CPSBC.

Are there any side effects?

Side effects are generally mild and temporary, such as nausea or a feeling of warmth during the infusion. These are easily managed by our medical staff by adjusting the infusion speed.

How much does NAD+ Therapy cost?

Cost depends on the delivery method (IV vs. injection) and the dosage required. Contact us for current pricing and package options.

Can I combine NAD+ with other treatments?

Yes, many patients combine NAD+ with other anti-aging treatments like Morpheus8 or injectables to support the body's natural healing and collagen-building processes.

Next Steps

If you are ready to explore how cellular health can transform your quality of life, the first step is a professional assessment. Our team is dedicated to helping you navigate the science of longevity with clarity and confidence.

Ready to See What NAD+ Therapy Can Do for You? Our medical team at SkinArtMD in Burnaby is ready to create your personalized treatment plan. Book your complimentary consultation today — available in English and Chinese.

Disclaimer: This article is for educational purposes only and does not constitute medical advice. Please consult with a qualified healthcare professional before undergoing any treatment.